Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 24

030320_coronavirus_image_from_cdc

 

Using western blot analysis, the investigation observed that SARS-CoV-2 S was virtually entirely processed at the S1/S2 site during biosynthesis in HEK239T cells, presumably by furin in the golgi compartement. This observation contrast with SARS-CoV S, which was incorporated into pseudovirus largely uncleaved.

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