Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 14

030320_coronavirus_image_from_cdc

 

As the coronavirus S glycoprotein in surface-exposed and mediates entry into host cells, it is the main target of neutralizing antibodies (Abs) upon infection and the focus of therapeutic and vaccine design. S trimers are extensively decorated with N-linked glycans that are important for proper folding and for modulating accessibility to host proteases and neutralizing Abs.

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