Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 13

030320_coronavirus_image_from_cdc

 

MERS-CoV  S, however, uses domain A to recognize non-acetylated sialoside attachment receptors, which likely promote subsequent binding of domain B (SB) to the entry receptor, dipeptidyl-peptidase 4. SARS-CoV and several SARS-related coronaviruses (SARSr-CoV) interact directly with angiotensin-converting enzyme 2 (ACE2) via SB to enter target cell.

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