Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 12

030320_coronavirus_image_from_cdc

 

Different coronaviruses use distinc domains within the S1 subunit to recognize a variety of attachment and entry receptors, depending on the viral species. Endemic human coronaviruses OC43 and HKU1 attach via their S domain A to 5-N-acetyl-9-O-acetyl-sialosides found on glycoproteins and glycolipids at the host cell surface to enable entry into susceptible cell.

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