In addition to the highly pathogenic zoonotic pathogens SARS-CoV, MERS-CoV, and SARS-C0V-2, all belonging to the β-coronavirus genus, four low-pathogenicity coronaviruses are endemic in humans: HCoV-OC43, HCoV-HKU1, HCoV-NL63 and HCoV-229E. To date, no therapeutics or vaccines are approved against any human-infecting coronavirus.
