Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein part 10

030320_coronavirus_image_from_cdc

 

Coronavirus entry into host cells is mediated by transmembrane spike (S) glycoprotein that forms  homotrimers protuding fom the viral surface. S comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membrane (S2 subunit). For many CoVs, S is cleaved  at the boundary between the S1 and S2 subunits, which remain on-covalently bound in the perfusion  conformation.

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