Structures and functions of Coronavirus proteins part 26

030320_coronavirus_image_from_cdc

 

At the same time, different residues (Lys113, Glu 173) were also predicted for this binding site. On the other hand, mutation analyses were done on these residues. The results reveal that these mutations cause destabilization effect of protein structures  and the interaction between this protein and the nsp3 protein is disrupted. Consequently, these residues have an important role in virus replication.

 

 

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