Structures and functions of Coronavirus proteins part 26



At the same time, different residues (Lys113, Glu 173) were also predicted for this binding site. On the other hand, mutation analyses were done on these residues. The results reveal that these mutations cause destabilization effect of protein structures  and the interaction between this protein and the nsp3 protein is disrupted. Consequently, these residues have an important role in virus replication.



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