Structures and functions of Coronavirus proteins part 25

030320_coronavirus_image_from_cdc

 

The MHV nsp3 protein 3D structure is available, therefore there was no need  to create a homology model, thus this crystal structure is used for docking. Then, this  research group has studied protein-protein docking  with N and nsp3 complex in order to illuminate amino acids, which play an important role in virus replication, and reveal replication mechanism of those functions in the epitope portions. As a result, binding site of N proteins Arg 125, Tyr 127 and Tyr 190 residues overlap with the experimental study.

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