Structures and functions of Coronavirus proteins part 18


Clarification of structure MHV N protein and determinants of interaction with nsp3 protein via the molecular modeling methods

The nucleocapsid (N) protein plays an essential role in the virus structure, the replication and transcription of CoV via interactions with the large positive-strand RNA viral genome. It is also shown that it plays a significant role in the pathogenesis of mouse hepatitis virus (MHV) and human CoV-induced diseases (SARS-CoV, MERS-CoV) which is a major determinant of virulence. Therefore, it is necessary to determinate structure of N to understand the replication and transcription mechanism.

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