The newly structural synthesized proteins are released into the endoplasmic reticulum. All of these proteins, along with the N protein, are linked to the viral genomic RNA and localized in the ERGIC region. Although, N protein is known to be necessary for coronavirus replication, the specific role that this protein plays in this process remains unknown. But, many studies suggest that N protein interaction with nsp3 plays a critical  role in the virus replication early in infection.