The coronaviruses (CoVs) are species of virus belonging to the Nidovirales order, which includes Coronaviridae, Arteriviridae, Roniviridae and Mesoniviridae families. The Coronaviridae  family is the largest one of the four family, by its genomic sizes of coronaviridae range from 26 to 32 kb. Coronviridae virus family subdivided into two subfamilies, coronavirinae and torovirinae . It is now divided into four genera, Alpha coronaviruses, Beta coronaviruses, Gamma coronaviruses and Delta coronviruses.