Receptor Recognition Mechanism of Coronaviruses part 62

030320_coronavirus_image_from_cdc

 

It is a successful viral strategy to steal a host protein and evolve it into viral RBDs with novel protein  receptor specificities or altered sugar receptor specificities. For example, MHV and BCoV S1-NTDs have the structural fold as human galectins, but they recognize a novel protein receptor and a different sugar receptor, respectively.

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