Receptor Recognition Mechanism of Coronaviruses part 60

030320_coronavirus_image_from_cdc

 

The strucrural studies of coronavirus-receptor interactions have established the virology principles. Drastic structural changes in viral RBDs can still lead to recognition of  a virus-binding hot spot on the same receptor protein. Supporting this principle is the finding that SARS-CoV and HCoV-NL63 recognize a common virus-binding hot spot on ACE2 using structurally divergent S1-CTDs.

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