Receptor Recognition Mechanism of Coronaviruses part 59

030320_coronavirus_image_from_cdc

 

In the VBMs of both ACE2 and CEACAM1, virus-binding hot spots have been identified and contribute significant energy to virus/receptor binding interactions. Therefore, host cell surface molecules are not randomly selected by viruses as their receptors. In fact, there are structural and evolutional reasons behind these selections by viruses.

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