Receptor Recognition Mechanism of Coronaviruses part 51

030320_coronavirus_image_from_cdc

 

Influenza virus lectins display  diverse sugar-binding modes, but they share a feature–their sugar-binding sites are all located in cavities and are not easily  accessible to host antibodies and immune cells. As a comparison, the sugar-binding sites in host galectins are open  and easily  accessible.  It was thus hypothesized that these viral lectins all  originated from host galectins but have evolved to use hidden sugar-binding sites to evade host immune surveillance.

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