Receptor Recognition Mechanism of Coronaviruses part 48

030320_coronavirus_image_from_cdc

 

Although the crystal structures of α- and γ-coronavirus S1-NTDs are not available, they may also have the galectin fold for the following reason:

  • The conserved structural topology of S1-CTDs across  different coronavirus genera strongly suggests a similarly conserved structural topology of S1-NTDs across different coronavirus genera
  • The S1-NTDs of both α-genus TGEV and γ-genus IBV function as lectins, although the former recognizes both N-glycolylneuraminic acid (Neu5Gc) and N-acetylneuraminic acid (Neu5Ac) and the latter recognizes Neu5Gc

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