Receptor Recognition Mechanism of Coronaviruses part 47

030320_coronavirus_image_from_cdc

 

Ancestral cornaviruses stole a host galectine gene and inserted into the 5′ end of their spike gene, which became coronavirus S1-NTD. Since then, coronavirus S1-NTDs have undergone divergent evolution in three genera. β-genus BCoV S1-NTD has kept the lectin activity but evolved specifity for a different sugar receptor, Neu5,9Ac2.

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