Receptor Recognition Mechanism of Coronaviruses part 45

030320_coronavirus_image_from_cdc

 

The sugar-binding sites in BCoV S1-NTD and human galectins overlap, although human galectins recognize a different sugar receptor, galactose. Structural comparison between MHV and BCoV S1-NTDs revealed that subtle structural changes between the two S1-NTDs, mainly involving different conformations of RBM loops, explain why BCoV S1-NTD does not bind sugars.

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