Receptor Recognition Mechanism of Coronaviruses part 41

030320_coronavirus_image_from_cdc

 

Despite its galectin fold, MHV S1-NTD does not bind sugars, as revealed by sugar-binding  assays. Moreover, neither the RBM on MHV S1-NTD nor the VBM on CEACAM1 contains any sugar at the binding interface. Instead, MHV S1-NTD binds to CEACAM1 through exclusive protein-protein interaction.

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