Receptor Recognition Mechanism of Coronaviruses part 40

030320_coronavirus_image_from_cdc

 

The structural topologies of MHV S1-NTD and human galectins are identical, except that MHV S1-NTD contains two additional β-strands in one of the β-sheet layers. Compared with human galectins, MHV S1-NTD contains additional structural motifs on top of the core  that form a ceiling-like structure. The outer surface of this ceiling-like structure functions as RBM by binding to the VBM on the N-terminal Ig-like domain of CEACAM1.

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