Receptor Recognition Mechanism of Coronaviruses part 37

030320_coronavirus_image_from_cdc

 

HCOV-NL63 and SARS-CoV S1-CTDs underwent divergent evolution to attain different structures,  they might have further converged to recognize the same region on the same receptor. The common virus-binding hot spot on ACE2 might be the driving force for this later convergent evolution.

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