Receptor Recognition Mechanism of Coronaviruses part 36

030320_coronavirus_image_from_cdc

 

The different molecular mechanisms used by the two S1-CTDs to recognize ACE2 suggest a convergent evolutionary relationship between the two S1-CTDs (i.e., the two S1-CTDs evolved independently to recognize the same virus-binding hot spot on ACE2), althogh a divergent evolutional relationship cannot be completely ruled out (i.e., the two S1-CTDs both evolved from a common ancestral protein that bound ACE2).

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