Receptor Recognition Mechanism of Coronaviruses part 35



Disturbance of the hot spot stucture via mutagenesis decreased or abolished the binding of both viruses. Hence, Lys353 and the nearby residues on ACE2 form a common virus-binding hot spot that is critical for the attachment of two different coronaviruses. On the other hand, among the three RBMs in HCoV-NL63 S1-CTD, only RBM1 and RBM2, but not RBM3, are involved  in binding the common virus-binding hot spot on ACE2, despite the fact that RBM3 is topologically equivalent to the RBM in SARS-CoV S1-CTD.

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