Receptor Recognition Mechanism of Coronaviruses part 33



However, structural topology analysis revealed that the secondary structural elements in HCoV-NL63 S1-CTD are connected in the same way as those in SARS-CoV S1-CTD, although two β-strands  in the former (strands β-1 and β-4) become α-helices in the latter (helices α-1 and α-4) and another β-strand (strand β-1) in the former is missing altogether in the latter. These results suggest that HCoV-NL63 and SARS-CoV S1-CTDs share an evolutionary origin and that the structural differences between the two S1-CTDs result from extensive divergent evolution.

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