Receptor Recognition Mechanism of Coronaviruses part 31



S1-CTDs of α-genus coronaviruses

α-genus HCoV-NL63 S1-CTD complexed with human ACE2 was the first crystal structure determined for an α-coronavirus S1 domain. This structure, along with the structure of β-genus SARS-CoV S1-CTD complexed with ACE2, provided the first view of how two different viruses recognize their common host receptor. The finding was intriguing.

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