Receptor Recognition Mechanism of Coronaviruses part 27



The S1-CTD of a SARS-CoV-related Rs3367 bat coronavirus contains two aspargines at the two positions (corresponding to positions 479 and 487 in human SARS-CoV strains). The first aspargine is favorable for human ACE2 binding, and the second is one less favorable. Thus, Rs3367 recognizes human ACE2 but probably less well than the human SARS-CoV. These structural studies of SARS-CoV S1-CTD/ACE2 interactions demonstrate that it is critical to understand viral evolution, cross-species transmission, and epidemics within a detailed structural framework.

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s