Receptor Recognition Mechanism of Coronaviruses part 25

030320_coronavirus_image_from_cdc

 

Structure-guided functional studies revealed that virus-binding hot spots provide significant energy to the virus-reseptor binding interactions. Indeed, all of the naturally selected viral mutations in SARS-CoV RBM surround the two hot spots, with significant impact on the structures of the hot spots, the ACE2 binding affinity, and the host immune responses.

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