Receptor Recognition Mechanism of Coronaviruses part 18

Posted on 10 April 2020 by

030320_coronavirus_image_from_cdc

 

The crystal structures of five coronavirus S1 domains complexed with their respective receptor have been determined:

  • β-genus SARS-CoV S1-CTD complexed with human ACE2
  • β-genus MERS-CoV S1-CTD complexed with human DPP4
  • α-genus HCoV-NL63 S1-CTD complexed with human ACE2
  • α-genus PRCV S1-CTD complexed with porcine APN
  • β-genus MHV S1-NTD complexed with murine CEACAM1
  • β-genus BCoV S1-NTD by itself has been determined with its sugar-binding site identified through mutagenesis

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