Receptor Recognition Mechanism of Coronaviruses part 13

030320_coronavirus_image_from_cdc

 

In addition to their viral receptor functions, the receptors for coronaviruses have their own physiological functions. ACE2 is a zinc-dependent carboxypeptidase that cleaves one residue from the C terminus of angiotensin peptides and functions in blood pressure regulation. ACE2 also protecs against severe acute lung failure, and SARS-CoV-induced downregulation of ACE2 promotes lung injury.

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