A recent study characterized more 229-E related coronaviruses discovered in hipposiderid bats from Ghana on full genome level. These bat coronaviruses were more diverdiversified and formed a single viral species with HCoV-229E. Interestingly, phylogenetic analysis revealed the intermediate position of a 229E-related alpaca virus between bat and human viruses. These findings suggested the ancestral origin of HCoV-229E in hipposiderid bats and the role of camelids as potential intermediate hosts was hypothesized.