Human coronaviruses part 40

030320_coronavirus_image_from_cdc

 

Although NeoCoV is closer to MERS-CoV than other bat coronaviruses at genomic level, the phylogenetic analysis of the spike protein showed that HKU4 is the most closely related to MERS-CoV among all currently known bat coronaviruses, sharing 67% sequence identity. This is  corelated with the capability of HKU4 of using DPP4 as its functional receptor. However, HKU4 preferred bat DPP4 over human DPP4, whereas MERS-CoV showed the opposite trend.

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