Of bone regeneration, osteonecrosis of femoral head has been the greatest focus for cell therapy . However, most reported studies were uncontrolled and used bone marrow aspirate concentrate. Prospective controlled studies using mesenchymal stem cells have recently been reported. More evidence will be accumulated to prove the effectiveness of stem cell treatment in arresting the progression of the disease. Large long-bone defect is the entity where regenerative medicine is most needed. Because of challenging nature of constructing a viable cell-scaffold composite,, clinical application of stem cells is still in its incipient stage
Clinical use of stem cells in orthopaedics part 70
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