Clinical use of stem cells in orthopaedics part 54

Stem cell 2


Another group analysed  the use of intra-articular injections of cultured  autologous bone marrow mesenchymal stem cells in conjuction with microfracture and medial opening-wedge high tibial osteotomy  Fifty-six knees in 56 patients with unicompartmental osteoarthritic knees and genu varum were randomly allocated to the cell-recipient group or control group. All patients underwent high tibial osteotomy and microfracture. The cell-recipient group  received intra-articular injection of cultured mesenchymal stem cells with hyaluronic acid 3 weeks after surgery, whereas the control group received only hyaluronic acid. After adjustment for age, baseline scores, and time of evaluation, the cell-recipient group showed  significantly better clinical and MRI scores (Wong et al., 2013).

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