Clinical use of stem cells in orthopaedics part 49

Stem cell 2

 

De Windt et al. performed phase I/II clinical trial with allogeneic mesenchymal stem cells mixed with either 10% or 20% recycled autologous  cartilage-derived cells to treat cartilage defects in 10 patients. At 12 months, all patients showed significant improvement in clinical outcome compared to baseline. MRI and second-look arthroscopies showed completely filled defects with regenerative cartilage tissue. Histological analysis indicated hyaline-like regeneration with a high concentration of proteoglicans and type II collagen. The regenerative tissue contained patient’s-own DNA only, indicating paracrine effect of allogeneic mesenchymal stem cells (De Windt et al., 2016)

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