Clinical use of stem cells in orthopaedics part 43

Stem cell 2


Haleem et al. reported a case series of culture-expanded autologous bone marrow stem cells transplanted into full-thickness cartilage defects of femoral condyles. Mesenchymal stem cells were carried in platelet-rich fibrin glue, and implanted, and covered with periosteal flap in 5 knees of 5 patients. The symptoms of all patients improved over the follow-up period of 12 moths. Functional scores for all patients showed statistically significant improvement  at 6 and 12 months postoperatively. MRI of three patients, at 12 months post operatively, revealed complete filling of the defects and complete surface congruity with native cartilage, whereas that of two patients showed incomplete congruity (Haleem et al., 2010)

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