As the  defect of articular cartilage is not amenable to conventional procedures such as microfacture, it can be a good candidate for regenerative therapy with stem cell implantation. More diffuse damage of articular cartilage, seen in osteoarthritis, may also become a target of stem cell therapy because the current treatment modalities do not offer a regenerative option for patients. Other candidates for stem cell treatment are degenerative tendon disorders, including advanced rotator cuff tears, which are not successfully treated by repair techniques.