To date, the literature supporting stem cell-based therapies comprises  mostly case reports or case series. Therefore, high-quality evidence, including from randomised clinical trials, is necessary to define the role of cell-based therapies in the treatment of musculoskeletal disorders.  It is imperative that clinicians who adopt  stem cell treatments in their practices possess a good understanding of the natural course of the disease. It is also highly recommended that treating  physicians do not thrust aside the concomitant use of established measures until stem cell therapy is evidently proved worthy in terms of efficacy and cost.