In recent year there is growing interest about the role of stem cell therapy in disease. Stem cell therapy has been used in treating many disease conditions with a greater understanding of their biology, a major role of stem cells in the malignant process has been proposed. Breast cancer remains the most common malignancy among women worldwide, it is believed that cancer targeted therapies especially stem cell targeted therapy are superior to current treatments such as traditional chemotherapy or radiotherapy to overcome recurrence, metastasis and chemo-resistance.