Another research group used three factors to stimulate endogenous hematopoietic progenitor cells (HPC). GCSF and AMD3100, CXCR4 antagonist, and SDF-1α facilitated the mobilization and migration of bone marrow derived hematopoietic progenitor cell (BM-HPCs) into brain. Alzheimers disease model mice were improved memory as well as hippocampal neurogenesis in alzheimers disease animal models after treatment of three factors, whereas beta-amyloid deposisition was not changed. These factors may act synergistically to migrate HPC and to produce a therapeutic effect. Fluoxetine treatment was shown the neuronal differentiation and protective effects of NSCs against beta-amyloid induced cell death.