In order to make  the transition of induced pluripotent stem cell-based therapy from lab to clinic, recently conducted research studies are focusing on identifying new molecular strategies that can increase cell reprogramming  efficiency without causing genetic and epigenetic abnormalities in the induced pluripotent stem cells. Several types of non-integrating methods have been developed [use of non-integrating adenoviral vectors, repeated transfection of plasmids, Cre-loxP-mediated recombination, PiggyBact-transposition].