Since then, induced pluripotent stem cells technoly provides a historic opportunity to move away from embryo destruction and opened a new era of personalized medicine. Patient-specific induced pluripotent stem cells  may be helpful in drug screening, generating in vitro models of human diseases, and novel reproductive techniques. In vitro, patient-specific induced pluripotent stem cells can differentiate  to specific cell types which enable testing of new drugs in patient-specific conditions. Since induced pluripotent stem cells -derived cells are generated from somatic cells previously obtained from a patient, there is no risk of immune rejection after their transplantation. The development of reproductive technology enables generation of gametes (sperm and eggs) from induced pluripotent stem cells. This technique could be helpful for treating infertility, however, the use of induced pluripotent stem cells-derived gametes raises set of ethical concerns related to the potential exploitation of created embryos, human NT, and risk of change natural reproduction including the possibility to derive gametes for same-sex reproduction, as well as in the asexual reproduction.