Ethical and safety issues of stem cell-based therapy part 11

Stem cell 5


Recently, Song and co-workers, reported that subretinal transplantation of human embryonic stem cell-derived retinal pigment epithelial cells in four Asian Patients: two with dry age-related macular degeneration and two with Stargardt macular dystrophy was safe and well tolerated procedure. Visual acuity improved 9-19 letters in three patients and remained stable [+1 letter] in one patient. During one year follow up period, serious safety issues related to the transplanted cells such as: adverse proliferation, tumorigenicity, ectopic tissue formation, was not observed. Based on these encouraging results, during the past few years, several clinical trials are investigating therapeutic potential of human embryonic stem cells -derived retinal pigment epithelial cells in patients with Stargardt macular dystrophy and advanced dry age related macular degeneration.

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