Treatment is multifactorial. Environmental measures to eliminate allergen exposure should always be attempted. Inhaled corticosteroids remain the mainstay of medical treatment as they down-regulate multiple inflammatory reactions in the lungs. Other adjuncts such as leukotriene receptor antagonists modify significant mediators of allergic inflammation present in asthmatic airways. Newer treatments include monoclonal antibodies directed against IgE (anti-IgE therapy), which have shown some success in decreasing asthma symptoms and the need for oral or inhaled corticosteroids.