Immunological aspects of allergy and anaphylaxis part 33

Allergy

 

Magone and colleagues applied such a model to evaluate the role of various cytokines, including IL-4, IFN-γ, and IL-12, in the early and late phases of ocular allergy using knockout (KO) mice and neutralizing antibodies. In this model,  multiple mice experimental groups, including:

  • ragweed-sensitized wild type
  • IL-4KO type
  • IL-12KO type
  • IFN-γKO type
  • anti-IL-12/mAb-treated
  • anti-IFN-γ m-Ab-treated mice were challenged with ragweed allergen ten days after immunization.

An additional group received recombinant murine IL-12. They found the anti IL-12 antibody-treated and IL-12KO type mice failed to show allergic cellular infiltration into the conjunctiva. IFN-γKO type mice, however, had a significantly stronger immediate-type hypersensitivity reactions and prolonged allergic cellular infiltration after ragweed exposure. Overall, their data provided evidence of IL-12 as an inducer of the late phase of ocular allergy. Additionally, the data suggest IFN-γ as a limiting factor of the late phase and a potential therapeutic cytokine in the prevention of chronic allergic disease. Further research is aimed at preventing initial sensitization to allergens.

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