Inflammatory markers include up-regulation of intercellular adhesion molecules such as ICAM-1. Increased levels of helper T cell 2 subset (TH2) cytokines, including IL-4, are found in the eye tissues during allergy season. Clinically, the conjunctiva is red, with a clear  discharge . The  eye is almost uniformly  pruritic. Seasonal allergic  conjunctivitis is commonly associated  with rhinitis, but it may be the predominant symptom of allergy.