Inflammatory markers include up-regulation of intercellular adhesion molecules such as ICAM-1. Increased levels of helper T cell 2 subset (TH2) cytokines, including IL-4, are found in the eye tissues during allergy season. Clinically, the conjunctiva is red, with a clear discharge . The eye is almost uniformly pruritic. Seasonal allergic conjunctivitis is commonly associated with rhinitis, but it may be the predominant symptom of allergy.