Immunological aspects of allergy and anaphylaxis part 22

Allergy

 

ALLERGIC CONJUNCTIVITIS

The eye, one of the initial exposure interfaces for allergens, is a common site for allergic disorders. Symptoms can range from mild eye itching to chronic  cataracts and blindness. These disorders are differentiated by their clinical presentation as well as by the nature of immunological changes occuring  in the conjunctival surface. Ocular allergic inflammation is typically associated with IgE-mediated  mast cell activation. Mast cell-derived mediators (eg histamine, proteases, leukotrienes, and cytokines) initiate a cascade of events that culminate in the infiltration and migration of inflammatory leukocytes (neutrophils, eosinophils, and lymphocytes) to the ocular tissue. This trafficking of inflammatory cells requires attraction of these cells initiated by chemokines, and directed migration of the inflammatory cells out the bloodstream to the surface epithelium using adhesion molecules and their receptors.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s