In recent years, natural rubber latex has been recognized as a source of anaphylaxis. Exposure can occur through contact or inhalation, and various scenarios of exposure include surgical procedures, dental exams, or sexual intercourse with latex condoms. Health care workers and spina bifida patients are particularly at risk. IgE antibodies to latex antigen Hev b1 have been demonstrated by immunoassay and are felt to play a pathogenic role in this clinical entity.