Immunological aspects of allergy and anaphylaxis part 11



In the immediate phase, preformed enzymes and toxic mediators such as histamine, tryptase, and heparin are the predominant bioactive substances released. Acting on H1 and H2 receptors, histamine promotes multiple effects such as increased vascular permeability, vasodilatation, constriction of bronchial smooth muscle, and increased mucous secretion.

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