Immunological aspects of allergy and anaphylaxis part 10

Allergy

 

Generally, antigen-spesific IgE antibodies on mast cells, or basophils, interact with previously encountered antigens mediating anaphylaxis. Mast cells are found in large numbers beneath cutaneous and mucosal surfaces and are closely associated with blood vessels and peripheral nerves. Basophils, most closely related to eosinophils, function similarly to mast cells. Basophils are present in the circulation, while mast cells are present only in tissue but in much greater numbers. When either of these cells types is triggered, a biphasic release of mediators occurs. The pathophysiology of anaphylaxis is clinically defined by the physiological effects of the immediate-phase and late-phase mediators on the target organs. By definition, anaphylaxis involves the cardiovascular, respiratory, gastrointestinal, or epidermal system; in most cases, multiple organs are involved.

Advertisements

About azaleaazelia

A nice person... :)
This entry was posted in Tak Berkategori. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s