CELLULAR VACCINES

Vaccines have been based on this strategy with particular emphasis on the use of naked DNA vaccines and live recombinant vectors, for example, naked DNA vaccines expressing the HIV-1 gag gene and either IL-12 or IL-15, which was developed by Wyeth and is presently in several phase I trials in the United states, Brazil, and Thailand. DNA vaccines have been found  to be most useful as priming vaccines in prime-boost strategies, using live recombinant vaccines for booster immunization,